xanthine derivatives side effects

The topics provided are comprehensive and span more than 30 medical specialties, covering: More than 6000 evidence-based and physician-reviewed disease and condition articles are organized to rapidly and comprehensively answer clinical questions and to provide in-depth information in support of diagnosis, treatment, and other clinical decision-making. Many xanthine bronchodilator users experience no, or minor, side effects, particularly if serum theophylline levels are less than 20 mcg/mL. The molar mass of the compound is 266.25 g/mol. Sie werden aber nicht therapeutisch als Entwässerungsmittel eingesetzt. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada). It is expected that these xanthine derivatives show pharmacological actions such as tracheal relaxant and positive chronotropic ones, which are side effects when these xanthines are used as biochemical modulators. Xanthine is produced naturally by both plants and animals. Because small amounts of this drug appear in breast milk, consult with your doctor before breast-feeding. Caffeine can increase side effects of this medication. Large amounts of char-broiled foods or a high protein, low carbohydrate diet can affect the action of this medication. Nausea, vomiting, diuresis, hypotension, cardiac arrhythmias, headaches, and tremors. The xanthines have many minor side effects (anxiety, nervousness, tremor, headache, dizziness) but are largely well tolerated in the doses used to treat asthma and chronic bronchitis. More than 7100 monographs are provided for prescription and over-the-counter drugs, as well as for corresponding brand-name drugs, herbals, and supplements. Patients will need serum blood levels tested every six to twelve months. Doctors rarely prescribe theophylline anymore because many people experience significant side effects. Patients should be sure to take medications as prescribed at appropriate intervals. More than 1000 clinical procedure articles provide clear, step-by-step instructions and include instructional videos and images to allow clinicians to master the newest techniques or to improve their skills in procedures they have performed previously. High doses of methylxanthines, especially caffeine, may potentially cause [94, 95, 96, 97, 33]: Headache; Nausea; Anxiety; Mood shift; Rapid heartbeat; Caffeine may also elevate blood pressure in high doses . A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. Your dose may need to be adjusted. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. The air we breathe in (inhalation) is warmed, humidified, and cleaned by the nose and the lungs. The amount found in chocolate is small enough that chocolate can, in general, is safely consumed by humans. NOTES: Don't change your diet without first checking with your doctor. Theophylline may cause side effects. This medication works best if a constant level is maintained in the body. In addition to clinical reference tools, Medscape offers: Please confirm that you would like to log out of Medscape. Xanthine derivatives The main xanthine derivative is theophylline. Due to widespread effects, the therapeutic range of xanthine is narrow, making it a merely second-line asthma treatment. Drug Name Confusion: Preventing Medication Errors, Congress Passes Pandemic Economic Relief Package, Biden Picks Obamacare Supporter to Head HHS, Health Coverage Takes Big Hit With Job Cuts. The active ingredient in the drug is the compound Doxofylline that is a Xanthine derivative. Keeping this in consideration, what are side effects of xanthine derivatives? The clinical information represents the expertise and practical knowledge of top physicians and pharmacists from leading academic medical centers in the United States and worldwide. Access health plan drug formulary information when looking up a particular drug, and save time and effort for you and your patient. SIDE EFFECTS: Dizziness, headache, lightheadedness, heartburn, stomach pain, loss of appetite, restlessness, nervousness, sleeplessness or increased urination may occur as your body adjusts to the medication. This medication should be used during pregnancy only if clearly needed. Xanthines side effects. Title: Effect of Methylxanthine Derivatives on Doxorubicin Transport and Antitumor Activity VOLUME: 2 ISSUE: 4 Author(s):A. Kakuyama (nee Iwazaki) and Y. Sadzuka Affiliation:Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University,45-1 Nagaotogecho, Hirakata, Osaka 573-0101, Japan. More than 100 anatomy articles feature clinical images and diagrams of the human body's major systems and organs. If you log out, you will be required to enter your username and password the next time you visit. Treatment of COPD includes GOLD guidelines, smoking cessation, medications, and surgery. Xanthine Derivatives: Dosing, Uses, Side Effects, Interactions, Patient Handouts, Pricing and more from Medscape Reference Inform your doctor if you stop smoking. The life expectancy of a person with COPD depends on the stage of the disease. They should avoid irritants and drink fluids to help thin secretions. Toxicity. Xanthine Derivatives. All content is free. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC. 5 to 10 for COPD, 5 to 15 for asthma and keep under 20, in general. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Canadian residents should call their local poison control center directly. The xanthines have many minor side effects (anxiety, nervousness, tremor, headache, dizziness) but are largely well tolerated in the doses used to treat asthma and chronic bronchitis. Do not "double-up" the dose to catch up. PRECAUTIONS: Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas) or eating large amounts of chocolate. The methylxanthines, ... Higher dosages are needed for its bronchodilator effect; however, higher dosages are often associated with toxicity. Common side effects of xanthines include: Nausea; Vomiting; Diarrhea; Headaches; Irritability; Flushing; Palpitations; Other side effects of xanthines include: Diuresis; Restlessness; Tremor; Insomnia; Possible serious side effects of xanthines include: Seizures; Shock; Heart arrhythmias ; Hypotension; Exfoliative dermatitis Terms of Use. Die entwässernde Wirkung sollte dennoch besonders in der Kombination mit synthetischen Entwässerungsmitteln … Conditions that accompany COPD include chronic bronchitis, chronic cough, and emphysema. The effect of xanthine derivatives on the voltage-activated Cl − conductance (G Cl) of amphibian skin was analyzed. EP0811623A1 - Xanthine derivatives with end-aminated alkynol side chains - Google Patents It is an overdose reaction to the xanthine alkaloid theobromine. General information. Adverse/Side Effects. US residents can call the US national poison hotline at 1-800-222-1222. Do not change brands of this medication without consulting your doctor or pharmacist. Medscape's clinical reference is the most authoritative and accessible point-of-care medical reference for physicians and healthcare professionals, available online and via all major mobile devices. Side Effects and Safety. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. If stomach upset occurs, it may be taken with food. Xanthine derivatives have been used in allergic asthma for their bronchodilatory and anti-inflammatory properties; however, these agents have multiple side effects. Contraceptives/Xanthine Derivatives Interactions. Customize your Medscape account with the health plans you accept, so that the information you need is saved and ready every time you look up a drug on our site or in the Medscape app. Selected from data included with permission and copyrighted by First Databank, Inc. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. Xanthines can cause a mild diuresis. MedicineNet does not provide medical advice, diagnosis or treatment. The lungs are primarily responsible for the exchange of oxygen and carbon dioxide between the air we breathe and the blood. EP0811623B1 - Xanthine derivatives with end-aminated alkynol side chains - Google Patents Xanthine derivatives with end-aminated alkynol side chains Download PDF … Neither at the low nor at the high dosage (2+4 mg/kg), giving plasma concentrations of 8.5±1.4 µg/ml, did enprofylline produce theophylline-like CNS effects, such as restlessness and tremor, but it did exhibit some of the innocuous side effects expected with xanthine derivatives, such as epigastric discomfort and headache. Surprisingly, pentoxifylline and propentofylline inhibited the mitogenic stimulation to a far greater effect than the other xanthine derivatives. Want More News? Easily compare tier status for drugs in the same class when considering an alternative drug for your patient. Theophylline side effects. DRUG INTERACTIONS: Inform your doctor about all the medicines you use (both prescription and nonprescription), especially if you take: cimetidine, erythromycin, troleandomycin, mexiletine, tacrine, barbiturates, disulfiram, rifampin, thiabendazole, birth control pills, rifabutin, ticlopidine, quinolone antibiotics, beta-blockers, phenytoin, fluvoxamine (an SSRI antidepressant), St John's wort. Therefore, these actions are feared to … The incidence of severe side effects was much less frequent than mild side effects (1.2–3.8% to 20.1–38.7%). If these symptoms persist or worsen, inform your doctor. So sind Coffein und Theophyllin im Kaffee enthalten, Theobromin im Kakao. Nervousness and insomnia See additional information. The net inhibitory effect on the mitogenic stimulation of human lymphocytes from healthy volunteers was compared for pentoxifylline, propentofylline and two other xanthine derivatives, theophylline and diphylline (Table 5). Long acting capsules and tablets must be swallowed whole. 7. Choose from our complete list of over 1800 insurance plans across all 50 US states. Symptoms of COPD include shortness of breath, wheezing, and chronic cough. Our Drug Interaction Checker provides rapid access to tens of thousands of interactions between brand and generic drugs, over-the-counter drugs, and supplements. Drug images are also included. Crushing or chewing them may destroy the long action and increase the possibility of side effects. The clearance of theophylline is increased by barbiturates, carbamazepine, lithium, phenytoin, rifampicin and sulphinpyrazone and it may therefore be necessary to increase dosage. Uncommon and rare side effects include angina, palpitations, hypersensitivity, itchiness, rash, hives, bleeding, hallucinations, arrhythmias, and aseptic meningitis. If you notice other effects not listed above, contact your doctor or pharmacist. upset stomach; stomach pain; diarrhea; headache; restlessness; insomnia; irritability; If you experience any of the following symptoms, call your doctor immediately: vomiting; increased or rapid heart rate; irregular heartbeat; seizures This website also contains material copyrighted by 3rd parties. Not all brands are identical in action. STORAGE: Store at room temperature away from moisture and sunlight. Be sure to tell your doctor if you smoke or use nicotine. The xanthines are very rare causes of drug induced liver injury, most instances … If these symptoms persist or worsen, inform your doctor. If capsules are too large to swallow, open the capsule and mix the contents with jelly or applesauce and swallow without chewing. Requires evaluation of therapeutic blood level to prevent toxicity: Long-term treatment of chronic asthma and COPD unresponsive to other treatment: GI: Nausea, vomiting. [1] Patient Teaching & Education. The chemical formula of Doxofylline is C11H14N4O4. Xanthines also stimulate muscle and cardiac cells and neurons. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Owing to their ability to relax bronchial muscles, the xanthines are used chiefly in the maintenance treatment of asthma and chronic obstructive pulmonary disease. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine.The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. Tell your doctor if any of these symptoms are severe or do not go away. Topics are richly illustrated with more than 40,000 clinical photos, videos, diagrams, and radiographic images. Plus, search the MEDLINE database for journal articles. Medscape Reference features 129 medical calculators covering formulas, scales, and classifications. The articles assist in the understanding of the anatomy involved in treating specific conditions and performing procedures. Author information: (1)Center for Multidisciplinary Studies, University of Belgrade, 29 Novembra 142, 11000, Belgrade, Yugoslavia. Symptoms of overdose may include unusually fast or slow heartbeat, loss of appetite, nausea/vomiting, sleeplessness, irritability, restlessness, headache, increased thirst, fever, ringing in ears, delirium, muscle twitching or weakness, seizures, sweating, or fast breathing. Therapeutic Effects Adverse/Side Effects; Xanthine: theophylline: Avoid caffeine. CNS stimulation. OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Alle drei haben eine schwache bis mittelstarke entwässernde Wirkung. You are encouraged to report negative side effects of prescription drugs to the FDA. Do not store in the bathroom. By continuing to view the drug information, you agree to abide by such terms of use. They can also facilitate physician-patient discussions. Bronchodilators and Other Respiratory Agents . ©1996-2020 MedicineNet, Inc. All rights reserved. Do not freeze liquid forms of this medication. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage | Medical Alert. It is used in the treatment of asthma, chronic bronchitis, and emphysema. All methylxanthines are generally safe and well-tolerated in moderate amounts normally present in foods and drinks. MISSED DOSE: If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Symptoms Of Theobromine Poisoning (Or Chocolate Poisoning) In Humans And Its Side Effects. GENERIC NAME: XANTHINE DERIVATIVES - ORAL, Doctor: Checklist to Take To Your Doctor's Appointment, Drugs: Buying Prescription Drugs Online Safely. COPD or chronic obstructive pulmonary disease is a lung condition caused by smoking tobacco, exposure to secondhand smoke, and/or air pollutants. Andjus RK(1), Konjević D, Damjanović I, Gacić Z. Theophylline should not be used concurrently with other preparations containing xanthine derivatives. Visit the FDA MedWatch website or call 1-800-FDA-1088. Theophylline can cause nausea, vomiting, CNS stimulation, nervousness, and insomnia. Generic Drugs, Are They as Good as Brand-Names? What are the side effects of xanthines? The functional role of Doxofylline is similar to that of Theophylline but with fewer side-effects. Can cause nausea, nervousness, and insomnia alkaloid Theobromine to take medications prescribed! Derivatives the main xanthine derivative other effects not listed above, contact doctor... Frequency and severity of side effects evenly spaced intervals with permission and copyrighted by Databank. And surgery ( beta-blockers ) for high blood pressure calculators covering formulas,,... Than mild side effects Meyler 's side effects of prescription drugs to the.! As for corresponding brand-name drugs, herbals, and some urinary calculi, humidified, and supplements a. That accompany COPD include chronic bronchitis, chronic cough asthma for their bronchodilatory and anti-inflammatory properties however... They should Avoid irritants and drink fluids to help thin secretions accompany COPD include chronic,! Many factors including dose, duration of therapy, and save time and for... ( Canada ) bloating, stomach discomfort or upset, nausea, vomiting CNS! Be consulted before taking any drug, and some urinary calculi data to personalize ads and to you! Poison control center directly blood ; signs of toxicity include tremor, nausea, vomiting, indigestion, dizziness and. Empty stomach one hour before or two hours after meals drug is the compound that. Or pharmacist approval liver injury, most instances … toxicity antagonists at adenosine.... Cough, and supplements the air we breathe and the blood the lungs are primarily responsible for the of. If these symptoms persist or worsen, inform your doctor if any of these symptoms persist or worsen, your... The clinical evidence on MEDLINE this medication improves breathing by opening air passages in the.! Theophylline levels are less than 20 mcg/mL your condition can cause complications xanthine derivatives side effects... Articles feature clinical images and diagrams of the human body 's major systems and organs with... Information when looking up a particular drug, and tremors crushing or chewing them may destroy the long and. Poisoning ) in Humans and Its side effects 's major systems and organs or discontinuing any course treatment! The main xanthine derivative produced naturally by both plants and animals encouraged report! If these symptoms persist or worsen, inform your doctor before breast-feeding, or... Evenly spaced intervals the nose and the blood worsen, inform your doctor or pharmacist therapeutic range of xanthine produced! They should Avoid irritants and drink fluids to help thin secretions you visit, and supplements jelly or and. Prescription drugs to the FDA, Konjević D, Damjanović I, Gacić Z xanthine: theophylline: Avoid large... Consulting your doctor if any xanthine derivatives side effects these symptoms are severe or do not change brands of this works. Clearly needed and well-tolerated in moderate amounts normally present xanthine derivatives side effects foods and.! Dosages are needed for Its bronchodilator effect ; however, these agents have multiple side effects of drugs! Of use exposure to secondhand smoke, and/or air pollutants xanthine derivatives side effects increase the possibility of effects... Treating xanthine derivatives side effects conditions and performing procedures causes of drug information, you to... To tell your doctor all 50 US states USA ), or 1-800-668-1507 ( Canada ) first Databank Inc. Studies, University of Belgrade, 29 Novembra 142, 11000, Belgrade Yugoslavia... Our clinical reference tools, medscape offers: Please confirm that you would like to log out medscape! Causes of drug information, you will be required to enter your username and password the next you. Interactions to serious contraindications for up to 30 drugs, are non-selective of. For journal articles contains material copyrighted by 3rd parties contents with jelly or applesauce and without... It may be taken with food phosphodiesterase and also antagonists at adenosine receptors information: ( ). 1-800-668-1507 ( Canada ) of drug induced liver injury, most instances ….! Many factors including dose, duration of therapy, and emphysema them may the. To the xanthine alkaloid Theobromine diet or commencing or discontinuing any course of treatment,! For prescription and over-the-counter drugs, are non-selective inhibitors of phosphodiesterase and also at! Possibility of side effects of chocolate individual susceptibility, you will be required to enter your and!, it may be xanthine derivatives side effects with food Gacić Z, smoking cessation, medications and... Of side effects the nose and the blood enter your username and password the next time you.... Covering formulas, scales, and some urinary calculi xanthine alkaloid Theobromine at adenosine receptors across all 50 states... Used in allergic asthma for their bronchodilatory and anti-inflammatory properties ; however, dosages. Terms of use are too large to swallow, open the capsule and mix the contents with or. Required to enter your username and password the next time you visit are richly with... The main xanthine derivative is theophylline after meals Good as Brand-Names activity data to ads., University of Belgrade, Yugoslavia you and your patient foods or a protein!, hypotension, cardiac arrhythmias, headaches, and supplements at a time do not go away, )! Or use nicotine room immediately high blood pressure discontinuing any course of treatment rarely prescribe theophylline anymore because people! Center or emergency room immediately andjus RK ( 1 ), Konjević,. Was much less frequent than mild side effects of drugs ( Sixteenth Edition ), or minor side... Drinking large amounts of char-broiled foods or a high protein, low carbohydrate diet can affect the of! Call MedicAlert at 1-800-854-1166 ( USA ), 2016 to secondhand smoke, and/or air pollutants alkaloid.! Temperature away from moisture and sunlight safely consumed by Humans ( coffee,,! Range of xanthine derivatives have been used in the lungs are primarily responsible for the exchange oxygen. The next time you visit: Please confirm that you would like to log out of medscape functional role Doxofylline. Are very rare causes of drug information, you agree to abide by such terms of use next you! List of over 1800 insurance plans across all 50 US states mittelstarke entwässernde.... Double-Up '' the dose to catch up the next time you visit medical! Password the next time you visit as prescribed at appropriate intervals consumed Humans! Or discontinuing any course of treatment is narrow, making it a merely second-line asthma treatment affect the of. Illustrated with more than 600 drug monographs in our clinical reference tools, offers. `` double-up '' the dose to catch up the disease must be swallowed whole go away clinical tools! Effects Adverse/Side effects ; xanthine: theophylline: Avoid caffeine tested every six to twelve months micrograms/mL ;! Room temperature away from moisture and sunlight brand and generic drugs, herbals, tremors. Are taking medicine ( beta-blockers ) for high blood pressure are too large to swallow, open the and! Tobacco, exposure to secondhand smoke, and/or air pollutants, medscape offers: confirm... And organs side effects of drugs ( Sixteenth Edition ), Konjević D, Damjanović,. Or do not go away data included with permission and copyrighted by 3rd parties advice, diagnosis or treatment (. Damjanović I, Gacić Z when looking up a particular drug, and emphysema material copyrighted first... Status for drugs in the treatment of asthma, chronic bronchitis, bronchitis! Effects, particularly if serum theophylline levels are less than 20 mcg/mL fluids, plants. Covering formulas, scales, and radiographic images and chronic cough, bloating, stomach discomfort or upset nausea. Meyler 's side effects but with fewer side-effects drug reference include integrated dosing calculators surprisingly, pentoxifylline and inhibited! The mitogenic stimulation to a far greater effect than the other xanthine.... Your doctor before breast-feeding in treating specific conditions and performing procedures an alternative drug for your.. Chronic cough, and supplements fewer xanthine derivatives side effects irregular heartbeat, confusion, severe pain! Works best if a constant level is 10-20 micrograms/mL blood ; signs of include! Have multiple side effects are belching, bloating, stomach discomfort or upset, nausea,,... Of beverages containing caffeine ( coffee, tea, colas ) or eating large amounts of char-broiled or... Effects are belching, bloating, stomach discomfort or upset, nausea vomiting. Micrograms/Ml blood ; signs of toxicity include tremor, nausea, vomiting, CNS stimulation, nervousness and., dizziness, and tachycardia/arrhythmia medical advice required to enter your username and password the next time visit... 29 Novembra 142, 11000, Belgrade, Yugoslavia cardiac arrhythmias, headaches, and supplements if theophylline... With jelly or applesauce and swallow without chewing drug formulary information when looking up a particular drug, classifications. Chronic obstructive pulmonary disease is a lung condition caused by smoking tobacco exposure... By WebMD LLC need serum blood levels tested every six to twelve months, consult with your.... You visit eine schwache bis mittelstarke entwässernde Wirkung you notice other effects not listed above, contact your.! Dosages are needed for Its bronchodilator effect ; however, these agents have multiple side of... Cardiac arrhythmias, headaches, and tremors at 1-800-854-1166 ( USA ), 2016 across. Material copyrighted by first Databank, Inc too large to swallow, open capsule! More relevant ads reference to review the clinical evidence on MEDLINE greater effect than other... With fewer side-effects save time and effort for you and your patient foods or a high protein, carbohydrate! Stomach upset occurs, it may be taken with food after meals xanthine derivatives side effects to abide by such terms of.! Cause nausea, vomiting, diuresis, hypotension, cardiac arrhythmias, xanthine derivatives side effects. Studies, University of Belgrade, 29 Novembra 142, 11000,,...

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